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PubMed Central
by Cao, Jia-ning; Agrawal, Anshu; Sharman, Edward; Jia, Zhenyu; Gupta, Sudhir
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This article is from PLoS ONE , volume 9 . Abstract Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age. The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. The expression levels of a total of 260 genes (1.8%) were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156347
Arxiv.org
by Geraldo A. Barbosa
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The human's visual system detect intensity images. Quite interesting, detector systems have shown the existence of different kind of images. Among them, images obtained by two detectors (detector array or spatially scanning detector) capturing signals within short window times may reveal a "hidden" image not contained in either isolated detector: Information on this image depend on the two detectors simultaneously. In general, they are called "high-order" images because they...
Source: http://arxiv.org/abs/1202.5434v1
PubMed Central
by Chopra, Pankaj; Papale, Ligia A; White, Andrew T J; Hatch, Andrea; Brown, Ryan M; Garthwaite, Mark A; Roseboom, Patrick H; Golos, Thaddeus G; Warren, Stephen T; Alisch, Reid S
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This article is from BMC Genomics , volume 15 . Abstract Background: Methylation on the fifth position of cytosine (5-mC) is an essential epigenetic mark that is linked to both normal neurodevelopment and neurological diseases. The recent identification of another modified form of cytosine, 5-hydroxymethylcytosine (5-hmC), in both stem cells and post-mitotic neurons, raises new questions as to the role of this base in mediating epigenetic effects. Genomic studies of these marks using model...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930898
PubMed Central
by Gariepy, Jean-Francois; Watson, Karli K.; Du, Emily; Xie, Diana L.; Erb, Joshua; Amasino, Dianna; Platt, Michael L.
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This article is from Frontiers in Neuroscience , volume 8 . Abstract Decisions made by individuals can be influenced by what others think and do. Social learning includes a wide array of behaviors such as imitation, observational learning of novel foraging techniques, peer or parental influences on individual preferences, as well as outright teaching. These processes are believed to underlie an important part of cultural variation among human populations and may also explain intraspecific...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982061
Defense Technical Information Archive
by Defense Technical Information Center
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The U. S. Navy Mine Defense Laboratory conducted a series of tests on a simulated nuclear submarine running light array at sea under normal nighttime operating conditions. The tests were made to determine the maximum range at which the light array could be recognized. Observers were selected from military personnel who normally stand duty watch as lookouts. Tests indicated that with an atmospheric transmission rate of 70% per nautical mile the maximum range of visibility for the lights in the...
Topics: DTIC Archive, Larrimore, Herbert, NAVY MINE DEFENSE LAB PANAMA CITY FL, *NUCLEAR POWERED SHIPS,...
Defense Technical Information Archive
by Defense Technical Information Center
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The present invention is a device for noninvasively measuring energy emissions in the human chest. This device includes first and second spaced longitudinal flexible supports. At least one transverse support means extends between the said first and second spaced longitudinal supports. A plurality of sensor means positioned in a spaced transverse array on the transverse support. This device is an array based measurement system that minimizes the effect of rib interaction on the space-time field...
Topics: DTIC Archive, Hull, Andrew J., DEPARTMENT OF THE NAVY WASHINGTON DC, *PATENT APPLICATIONS,...
Community Texts
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Ancient Ancestors, Pyramids, Aliens, Proofed through GPS vectors using radian mathematics using modern day technology. The science of Archaeocryptography founded by Carl P Munck.
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Topics: Ancient, Tesla, Pyramids, Mars, Earth, Science, Archaeocryptography
Defense Technical Information Archive
by Defense Technical Information Center
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Science fiction has long imagined a future populated with artificial humans- human-looking devices with human-like intelligence. Although Asimov's benevolent robots and the Terminator movies' terrible war machines are still a distant fantasy, researchers across a wide range of disciplines are beginning to work together toward a more modest goal building virtual humans. These software entities look and act like people and can engage in conversation and collaborative tasks, but they live in...
Topics: DTIC Archive, Gratch, Jonathan, UNIVERSITY OF SOUTHERN CALIFORNIA MARINA DEL REY CA INST FOR...
Defense Technical Information Archive
by Defense Technical Information Center
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A standardized reference target nomenclature been defined for a high speed photogrammetric system. High speed cameras record three-dimensional displacement of living human and non-human primate subjects undergoing impact accelerations. This motion is measured from the reference target. A standardized nomenclature of the location and orientation of each target face eliminates confusion when surveying multiple camera sites or on subsequent test setups. Keywords: Test methods; Lexicography; Target...
Topics: DTIC Archive, NAVAL BIODYNAMICS LAB NEW ORLEANS LA, *IMPACT ACCELERATION, *PHOTOINTERPRETATION,...
PubMed Central
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This article is from Genes , volume 2 . Abstract The TSPY gene stands out from all other human protein-coding genes because of its high copy number and tandemly-repeated organization. Here, we review its evolutionary history in great apes in order to assess whether these unusual properties are more likely to result from a relaxation of constraint or an unusual functional role. Detailed comparisons with chimpanzee are possible because a finished sequence of the chimpanzee Y chromosome is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924835
The behavior of two real-time computer simulation models of melody recognition was compared with the performance of human subjects in this study. One of the models, INT1, recognized melodies by comparing specific intervals with stored intervals. The other model, CONT1, performed by comparing the contour of the stimulus melody with an array of melody intervals. The 20 intermediate and advanced psychology majors who volunteered to participate in the study were tested on the speed and accuracy of...
Topics: ERIC Archive, Computer Simulation, Higher Education, Melody, Models, Multiple Regression Analysis,...
Defense Technical Information Archive
by Defense Technical Information Center
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The development of a high-resolution retinal prosthesis device at the Naval Research Laboratory (NRL) was first discussed in the late 1990s. At that time, NRL researchers and Office of Naval Research (ONR) Science Officers were studying the topic: Image Processing: What Can We Learn from the Retina? It had long been recognized that the retina must perform remarkable image processing functions, yet neuroscientists had only a limited understanding of the systemic mechanisms. ONR felt that...
Topics: DTIC Archive, NAVAL RESEARCH LAB WASHINGTON DC OPTICAL SCIENCES DIV, *LEARNING, *IMAGE PROCESSING,...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, *MAMMALS, *VISUAL PERCEPTION, *ELECTROENCEPHALOGRAPHY,...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
A review of previous mammalian visual systems neurological and psychological research is presented. Results of previous research motivated the development of a device that would record fine grained electroencephalic data from the surface of a living mammalian cortex. A multiplexing multielectrode array has been developed and tested for this purpose. The device consists of a four by four array of electrodes and sixteen junction field effect transistors fabricated on a silicon substrate using...
Topics: DTIC Archive, Fitzgerald,Gary H, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF...
PubMed Central
by Buard, Jerome; Rivals, Eric; Dunoyer de Segonzac, Denis; Garres, Charlotte; Caminade, Pierre; de Massy, Bernard; Boursot, Pierre
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This article is from PLoS ONE , volume 9 . Abstract In humans and mice, meiotic recombination events cluster into narrow hotspots whose genomic positions are defined by the PRDM9 protein via its DNA binding domain constituted of an array of zinc fingers (ZnFs). High polymorphism and rapid divergence of the Prdm9 gene ZnF domain appear to involve positive selection at DNA-recognition amino-acid positions, but the nature of the underlying evolutionary pressures remains a puzzle. Here we explore...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890296
A Lunar Optical UV-IR Synthesis Array (LOUISA) proposed to take advantage of the characteristics of the lunar environment requires appropriate advances in technology. These technologies are in the areas of contamination/interference control, test and evaluation, manufacturing, construction, autonomous operations and maintenance, power and heating/cooling, stable precision structures, optics, parabolic antennas, and communications/control. LOUISA needs to be engineered to operate for long...
Topics: NASA Technical Reports Server (NTRS), INFRARED SPECTRA, LUNAR ATMOSPHERE, LUNAR BASES, PARABOLIC...
PubMed Central
by Shi, Jinghong; Gao, Lidong; Zhu, Yun; Chen, Tao; Liu, Yunzhi; Dong, Libo; Liu, Fuqiang; Yang, Hao; Cai, Yahui; Yu, Mingdong; Yao, Yi; Xu, Cuilin; Xiao, Xiangming; Shu, Yuelong
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This article is from PLoS ONE , volume 9 . Abstract We investigated avian influenza infections in wild birds, poultry, and humans at Eastern Dongting Lake, China. We analyzed 6,621 environmental samples, including fresh fecal and water samples, from wild birds and domestic ducks that were collected from the Eastern Dongting Lake area from November 2011 to April 2012. We also conducted two cross-sectional serological studies in November 2011 and April 2012, with 1,050 serum samples collected...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995770
In order to promote public education and public safety, equal justice for all, a better informed citizenry, the rule of law, world trade and world peace, this legal document is hereby made available on a noncommercial basis, as it is the right of all humans to know and speak the laws that govern them. (For more information: 12 Tables of Code ) Name of Standards Organization: Bureau of Indian Standards (BIS) Division Name: Electrotechnical Section Name: Solar Photovoltaic Energy Systems (ETD 28)...
Topics: data.gov.in, standardsbis.in, public.resource.org
PubMed Central
by Oddo, Calogero Maria; Beccai, Lucia; Felder, Martin; Giovacchini, Francesco; Carrozza, Maria Chiara
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This article is from Sensors (Basel, Switzerland) , volume 9 . Abstract A compliant 2×2 tactile sensor array was developed and investigated for roughness encoding. State of the art cross shape 3D MEMS sensors were integrated with polymeric packaging providing in total 16 sensitive elements to external mechanical stimuli in an area of about 20 mm2, similarly to the SA1 innervation density in humans. Experimental analysis of the bio-inspired tactile sensor array was performed by using ridged...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297154
Operating in a dangerously sensor-limited closed environment, submarine sonar operators are plagued by primitive sensory interfaces inherited from earlier hardware designs. The inefficient match to the operator's perceptual capability is exacerbated as submarines increasingly operate in the littoral where, at now reduced ranges from quieter threat targets, detection requires immediate action for crew safety. Present use of the sonar operator's auditory ability ignores the superior acuity of the...
Topics: DTIC Archive, Russotti, Joseph S, NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT, *BEAM FORMING,...
Defense Technical Information Archive
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A technique using a plane temperature sensor array to dynamically image the transient temperature response of the human skin subject to intentionally applied heating or cooling was proposed. A human disease diagnostic system with satisfactory accuracy and rapid response speed was constructed. Preliminary experiments show the potential clinical application of this device, which is simple to fabricate and thus cheap in price. Further theoretical analysis shows that the surface heat flux may serve...
Topics: DTIC Archive, Liu, Jing, CHINESE ACADEMY OF SCIENCES BEIJING TECHNICAL INST OF PHYSICS AND...
PubMed Central
by Panova, Marina; Johansson, Tomas; Canback, Bjorn; Bentzer, Johan; Rosenblad, Magnus Alm; Johannesson, Kerstin; Tunlid, Anders; Andre, Carl
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This article is from BMC Genomics , volume 15 . Abstract Background: Array comparative genomic hybridization (aCGH) is commonly used to screen different types of genetic variation in humans and model species. Here, we performed aCGH using an oligonucleotide gene-expression array for a non-model species, the intertidal snail Littorina saxatilis. First, we tested what types of genetic variation can be detected by this method using direct re-sequencing and comparison to the Littorina genome draft....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148934
biorxiv
by Amy L. Williams; Giulio Geneovese; Thomas Dyer; Katherine Truax; Goo Jun; Nick Patterson; Joanne E. Curran; Ravi Duggirala; John Blangero; David Reich; Molly Przeworski; the T2D-GENES Consortium
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Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (or "gene conversion") resolutions. We report the first genome-wide study of non-crossover gene conversion events in humans. Using SNP array data from 94 meioses, we identified 107 sites affected by non-crossover events, of which 51/53 were confirmed in sequence data. Our results suggest that a site is involved in a non-crossover event at a rate...
Topic: Genetics
Source: http://biorxiv.org/content/early/2014/09/18/009175
PubMed Central
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This article is from Infection and Drug Resistance , volume 7 . Abstract Ticks are important vectors of disease and transmit an extensive array of bacterial, viral and protozoan diseases to both humans and dogs within a community. Borrelia burgdorferi, the causative agent of Lyme disease, has been extensively studied within both the human and veterinary population. Anaplasma phagocytophilum, an intracellular rickettsial pathogen also transmitted by ixodid ticks, has emerged as an important...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132225
PubMed Central
by Stimpson, Kaitlin M.; Sullivan, Lori L.; Kuo, Molly E.; Sullivan, Beth A.
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This article is from PLoS ONE , volume 9 . Abstract The short arms of the ten acrocentric human chromosomes share several repetitive DNAs, including ribosomal RNA genes (rDNA). The rDNA arrays correspond to nucleolar organizing regions that coalesce each cell cycle to form the nucleolus. Telomere disruption by expressing a mutant version of telomere binding protein TRF2 (dnTRF2) causes non-random acrocentric fusions, as well as large-scale nucleolar defects. The mechanisms responsible for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963894
PubMed Central
by Wang, Jiying; Jiang, Jicai; Wang, Haifei; Kang, Huimin; Zhang, Qin; Liu, Jian-Feng
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This article is from PLoS ONE , volume 9 . Abstract Copy number variations (CNVs) are important forms of genomic variation, and have attracted extensive attentions in humans as well as domestic animals. In the study, using a custom-designed 2.1 M array comparative genomic hybridization (aCGH), genome-wide CNVs were identified among 12 individuals from diverse pig breeds, including one Asian wild population, six Chinese indigenous breeds and two modern commercial breeds (Yorkshire and Landrace),...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903766
In order to promote public education and public safety, equal justice for all, a better informed citizenry, the rule of law, world trade and world peace, this legal document is hereby made available on a noncommercial basis, as it is the right of all humans to know and speak the laws that govern them. (For more information: 12 Tables of Code ) Name of Standards Organization: Bureau of Indian Standards (BIS) Division Name: Metallurgical Engineering Section Name: Refractories (MTD 15) Designator...
Topics: data.gov.in, standardsbis.in, public.resource.org
Books to Borrow
by Peck, Richard, 1934-
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In 1887, the nouveau riche Cranstons voyage from New York to London, where they hope to find a husband for their awkward older daughter, secretly accompanied by Helena and her mouse siblings, for whom the journey is both terrifying and wondrous as they meet an array of titled humans despite their best efforts at remaining hidden
Topics: Adventure and adventurers, Mice, Ocean travel, Human-animal relationships, Social classes, Brothers...
Arxiv.org
by Joseph K. Pickrell; Nick Patterson; Chiara Barbieri; Falko Berthold; Linda Gerlach; Tom Güldemann; Blesswell Kure; Sununguko Wata Mpoloka; Hirosi Nakagawa; Christfried Naumann; Mark Lipson; Po-Ru Loh; Joseph Lachance; Joanna Mountain; Carlos Bustamante; Bonnie Berger; Sarah Tishkoff; Brenna Henn; Mark Stoneking; David Reich; Brigitte Pakendorf
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Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, we report data from 23 populations analyzed at over half a million single nucleotide polymorphisms, using a genome-wide array designed for studying human history. The southern African Khoisan fall into two genetic groups, loosely corresponding to the northwestern and...
Source: http://arxiv.org/abs/1207.5552v2
Books to Borrow
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Includes bibliographical references (p. 307-350)
Topics: Marine animals, Endangered species
PubMed Central
by Zarnitsyna, Veronika I.; Evavold, Brian D.; Schoettle, Louis N.; Blattman, Joseph N.; Antia, Rustom
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This article is from Frontiers in Immunology , volume 4 . Abstract In order to recognize and combat a diverse array of pathogens the immune system has a large repertoire of T cells having unique T cell receptors (TCRs) with only a few clones specific for any given antigen. We discuss how the number of different possible TCRs encoded in the genome (the potential repertoire) and the number of different TCRs present in an individual (the realized repertoire) can be measured. One puzzle is that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872652
A study, to support the need for exploratory research, was designed to elicit a description of the medical chart located in its setting--the chart was looked "through" as a tool (as a means to an end to effect particular medical goals) and looked "at" itself as technology. This could provide a way to understand the relationship between the practice and the process of writing and material tools, a way to understand the relationship between the practice and the process of...
Topics: ERIC Archive, Charts, Information Sources, Medical Care Evaluation, Medical Education, Patients,...
PubMed Central
by Vinson, Gavin P; Brennan, Caroline H
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This article is from Endocrine Connections , volume 2 . Abstract Substantial evidence shows that the hypophyseal–pituitary–adrenal (HPA) axis and corticosteroids are involved in the process of addiction to a variety of agents, and the adrenal cortex has a key role. In general, plasma concentrations of cortisol (or corticosterone in rats or mice) increase on drug withdrawal in a manner that suggests correlation with the behavioural and symptomatic sequelae both in man and in experimental...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845705
PubMed Central
by Giovedi, Silvia; Corradi, Anna; Fassio, Anna; Benfenati, Fabio
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This article is from Frontiers in Pediatrics , volume 2 . Abstract Autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders characterized by deficits in social interaction and social communication, restricted interests, and repetitive behaviors. Many synaptic protein genes are linked to the pathogenesis of ASDs, making them prototypical synaptopathies. An array of mutations in the synapsin (Syn) genes in humans has been recently associated with ASD and epilepsy, diseases...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154395
Arxiv.org
by Davide Barbieri; Giovanna Citti; Gonzalo Sanguinetti; Alessandro Sarti
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The visual information in V1 is processed by an array of modules called orientation preference columns. In some species including humans, orientation columns are radially arranged around singular points like the spokes of a wheel, that are called pinwheels. The pinwheel structure has been observed first with optical imaging techniques and more recently by in vivo two-photon imaging proving their organization with single cell precision. In this research we provide evidence that pinwheels are de...
Source: http://arxiv.org/abs/1007.1395v1
This research investigated the feasibility of using a tactile display to transmit information via the scalp. The purpose of the study was to compare performance for various stimulus site configurations. The first phase of the study investigated the number of sites that could be reliably detected and identified for the front section and the rear section of the scalp. Also during this phase, a multi-position array condition was investigated to determine target identification performance at twelve...
Topics: DTIC Archive, Lambert, Marie E, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH, *MEMORY DEVICES,...
PubMed Central
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This article is from Frontiers in Neuroscience , volume 7 . Abstract Sustaining brain and cognitive function across the lifespan must be one of the main biomedical goals of the twenty-first century. We need to aim to prevent neuropsychiatric diseases and, thus, to identify and remediate brain and cognitive dysfunction before clinical symptoms manifest and disability develops. The brain undergoes a complex array of changes from developmental years into old age, putatively the underpinnings of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613699
This article is from Diabetes & Metabolism Journal , volume 38 . Abstract The burgeoning epidemic of metabolic disease causes significant societal and individual morbidity and threatens the stability of health care systems around the globe. Efforts to understand the factors that contribute to metabolic derangements are critical for reversing these troubling trends. While excess caloric consumption and physical inactivity superimposed on a susceptible genetic background are central drivers...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950190
PubMed Central
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This article is from BMC Medicine , volume 11 . Abstract Sexual development in humans is only partly understood at the molecular level. It is dependent on genetic control primarily induced by the sex chromosomal differences between males and females. This leads to the development of the gonads, whereby afterwards the differentiation of the apparent phenotype is controlled by hormone action. Sex steroids may exert permanent and temporary effects. Their organizational features of inducing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706224
Defense Technical Information Archive
by Defense Technical Information Center
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In May 1978, when the U.S. Air Force requested the National Research Council to assess certain aspects of its newest missile defense warning system then under construction at the Otis Air Force Base on Cape Cod, Massachusetts, the facility was the subject of intense public concern that exposure to its radiation emissions might be harmful to humans. The purpose of the radar facility, known as PAVE PAWS (PAVE being a code word for the Air Force unit in charge of the project PAWS and acronym for...
Topics: DTIC Archive, NATIONAL RESEARCH COUNCIL WASHINGTON DC ENGINEERING PANEL ON THE PAVE PAWS RADAR...
PubMed Central
by McCall, Matthew N.; Jaffee, Harris A.; Zelisko, Susan J.; Sinha, Neeraj; Hooiveld, Guido; Irizarry, Rafael A.; Zilliox, Michael J.
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This article is from Nucleic Acids Research , volume 42 . Abstract The Gene Expression Barcode project, http://barcode.luhs.org, seeks to determine the genes expressed for every tissue and cell type in humans and mice. Understanding the absolute expression of genes across tissues and cell types has applications in basic cell biology, hypothesis generation for gene function and clinical predictions using gene expression signatures. In its current version, this project uses the abundant publicly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965035
Arxiv.org
by S. N. Dorogovtsev; J. F. F. Mendes; J. G. Oliveira
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The distribution of numbers in human documents is determined by a variety of diverse natural and human factors, whose relative significance can be evaluated by studying the numbers' frequency of occurrence. Although it has been studied since the 1880's, this subject remains poorly understood. Here, we obtain the detailed statistics of numbers in the World Wide Web, finding that their distribution is a heavy-tailed dependence which splits in a set of power-law ones. In particular, we find that...
Source: http://arxiv.org/abs/physics/0504185v2
PubMed Central
by Moise, Leonard; Gutierrez, Andres H.; Bailey-Kellogg, Chris; Terry, Frances; Leng, Qibin; Abdel Hady, Karim M.; VerBerkmoes, Nathan C.; Sztein, Marcelo B.; Losikoff, Phyllis T.; Martin, William D.; Rothman, Alan L; De Groot, Anne S.
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This article is from Human Vaccines & Immunotherapeutics , volume 9 . Abstract Advances in the field of T cell immunology have contributed to the understanding that cross-reactivity is an intrinsic characteristic of the T cell receptor (TCR), and that each TCR can potentially interact with many different T cell epitopes. To better define the potential for TCR cross-reactivity between epitopes derived from the human genome, the human microbiome, and human pathogens, we developed a new...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974887
Mangroves are unique group of vascular plants that occur in saline coastal habitats and are known to tolerate extreme environmental conditions. Some mangrove plants are used for a wide range of conditions, including bacterial, fungal, and viral diseases. The rise of antibiotic-resistant microorganisms is one of the severe problems in healthcare systems of the world, and infectious diseases are the second most serious cause of death worldwide. Therefore, new drugs have to be found in order to...
Topics: Sesuvium, Bio active compounds, Antibacterial activity, Zoology
Defense Technical Information Archive
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This thesis proposes changes within the military to achieve a more balanced portfolio of capabilities in the array of tools the U.S. military has for executing the Long War. Through comparative analysis of the ongoing Long War to the nearly fifty year struggle of the Cold War, this paper identifies significant similarities and differences that form the basis for proposed changes in the military. The proposed changes call for an increase in human intelligence capability, a reexamination of...
Topics: DTIC Archive, NATIONAL DEFENSE UNIV NORFOLK VA JOINT ADVANCED WARFIGHTING SCHOOL, *MILITARY...
Books to Borrow
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Includes bibliographical references (p. 355-362) and index
Topics: Dogs, Dogs, Dogs, Human-animal relationships
Mendeley Climate Change Library
by Lucas S. Bair; Charles B. Yackulic; John C. Schmidt; Denielle M. Perry; Christine J. Kirchhoff; Karletta Chief; Benedict J. Colombi
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During the last 50 years, construction of dams in the western United States declined. This is partly because of increasing recognition of diverse and unintended social-ecological consequences of dams. Today, resource managers are recognizing the wide array of tradeoffs and are including a more diverse group of stakeholders in decision making for individual dams. Yet decisions at the regional scale maintain a focus on a limited number of resources and objectives, leading to inefficient and...
NASA Network Resource and Training Site
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This paper describes the MIcroDosimetry iNstrument (MIDN) mission now under development at the United States Naval Academy. The instrument is manifested to fly on the MidSTAR-1 spacecraft, which is the second spacecraft to be developed and launched by the Academy s faculty and midshipmen. Launch is scheduled for 1 September 2006 on an ATLAS-5 launch vehicle. MIDN is a rugged, portable, low power, low mass, solid-state microdosimeter designed to measure in real time the energy distributions of...
Topics: NASA Technical Reports Server (NTRS), DOSIMETERS, SOI (SEMICONDUCTORS), SOLID STATE, REAL TIME...
Human space travelers experience a unique environment that affects homeostasis and physiologic adaptation. The spacecraft environment subjects the traveler to noise, chemical and microbiological contaminants, increased radiation, and variable gravity forces. As humans prepare for long-duration missions to the International Space Station (ISS) and beyond, effective measures must be developed, verified and implemented to ensure mission success. Limited biomedical quantitative capabilities are...
Topics: NASA Technical Reports Server (NTRS), INTERNATIONAL SPACE STATION, AEROSPACE ENVIRONMENTS, GENE...
PubMed Central
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This article is from Virology Journal , volume 11 . Abstract Background: The Epstein-Barr virus (EBV) is a causal agent in a number of malignancies in humans including hematopoietic tumors and non-hematopoietic tumors. Burkitt’s lymphoma cell lines containing the Epstein-Barr virus have been shown to form tumors in nude mice while clonal derivatives of such cell lines in which the viral genome has been lost do not (JID 177: 1194-1201, 1998; JV 72: 9150-9156, 1998; JV 68: 6069-6073, 1994). The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072619
Defense Technical Information Archive
by Defense Technical Information Center
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The purpose of this investigation has been threefold: (1) to review the literature for experimental results which either contribute quantitative tolerance data or data supporting mechanisms or criteria of injury; (2) develop new methods of investigating neck response to indirect loading; (3) further refine a mathematical neck model. It has been found that retinal hemorrhage or mild concussion were the threshold injuries produced in forward facing harnessed individuals subjected to 39-45 g sled...
Topics: DTIC Archive, Hodgson, Voight R., WAYNE STATE UNIV DETROIT MI BIOENGINEERING CENTER,...
Defense Technical Information Archive
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We proposed to investigate the role of Bmi-1 (a member of polycomb gene family) in human prostate cancer (CaP) development. Here, we present the work accomplished during the first year of the project. Immunohistochemical analysis of prostatic specimens of 125 human CaP patients showed that Bmi-1 protein levels are highly elevated in patients with advanced disease. To understand the mechanism of action of Bmi-1, we employed two-prong strategy. Firstly, Bmi-1 was knocked down in CaP cells (LNCaP,...
Topics: DTIC Archive, MINNESOTA UNIV MINNEAPOLIS, *CELLS(BIOLOGY), *GENES, *PROSTATE CANCER, CYCLES,...
Defense Technical Information Archive
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We proposed to investigate the role of Bmi-1 (a member of polycomb gene family) in human prostate cancer (CaP) development. Here, we present the work accomplished during the first year of the project. Immunohistochemical analysis of prostatic specimens of 125 human CaP patients showed that Bmi-1 protein levels are highly elevated in patients with advanced disease. To understand the mechanism of action of Bmi-1, we employed two-prong strategy. Firstly, Bmi-1 was knocked down in CaP cells (LNCaP,...
Topics: DTIC Archive, WISCONSIN UNIV MADISON, *CELLS(BIOLOGY), *PROSTATE CANCER, DISEASES, GENES,...
PubMed Central
by Berglund, Jonas; Nevalainen, Elisa M; Molin, Anna-Maja; Perloski, Michele; Andre, Catherine; Zody, Michael C; Sharpe, Ted; Hitte, Christophe; Lindblad-Toh, Kerstin; Lohi, Hannes; Webster, Matthew T
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This article is from Genome Biology , volume 13 . Abstract Background: Copy number variants (CNVs) account for substantial variation between genomes and are a major source of normal and pathogenic phenotypic differences. The dog is an ideal model to investigate mutational mechanisms that generate CNVs as its genome lacks a functional ortholog of the PRDM9 gene implicated in recombination and CNV formation in humans. Here we comprehensively assay CNVs using high-density array comparative genomic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053742
PubMed Central
by Lehnert, Stefan; Kapitonov, Vladimir; Thilakarathne, Pushpike J; Schuit, Frans C
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This article is from BMC Genomics , volume 12 . Abstract Background: The total number of miRNA genes in a genome, expression of which is responsible for the miRNA repertoire of an organism, is not precisely known. Moreover, the question of how new miRNA genes arise during evolution is incompletely understood. Recent data in humans and opossum indicate that retrotranspons of the class of short interspersed nuclear elements have contributed to the growth of microRNA gene clusters. Method: We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212979
NASA Network Resource and Training Site
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A safe, non-invasive method for forming images through clothing of large groups of people, in order to search for concealed weapons either made of metal or not, has been developed. A millimeter wavelength scanner designed in a unique, ring-shaped configuration can obtain a full 360 image of the body with a resolution of less than a millimeter in only a few seconds. Millimeter waves readily penetrate normal clothing, but are highly reflected by the human body and concealed objects. Millimeter...
Topics: NASA Technical Reports Server (NTRS), FABRICATION, HUMAN BODY, RADIO FREQUENCIES, IMAGES,...
PubMed Central
by Den Boer, Jeroen W; Euser, Sjoerd M; Nagelkerke, Nico J; Schuren, Frank; Jarraud, Sophie; Etienne, Jerome
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This article is from BMC Genomics , volume 14 . Abstract Background: Legionella is a water and soil bacterium that can infect humans, causing a pneumonia known as Legionnaires’ disease. The pneumonia is almost exclusively caused by the species L. pneumophila, of which serogroup 1 is responsible for 90% of patients. Within serogroup 1, large differences in prevalence in clinical isolates have been described. A recent study, using a Dutch Legionella strain collection, identified five virulence...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701591
PubMed Central
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This article is from Asian Journal of Andrology , volume 16 . Abstract Over the last few decades, there have been numerous reports of adverse effects on the reproductive health of wildlife and laboratory animals caused by exposure to endocrine disrupting chemicals (EDCs). The increasing trends in human male reproductive disorders and the mounting evidence for causative environmental factors have therefore sparked growing interest in the health threat posed to humans by EDCs, which are...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901886
Community Texts
by Shaykh Abdillah Sulaymān Ibn Nasir Ibn ‘Abdillah Al-‘Ulwan
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Verily The Victory Of Allah Is Near.pdf Shaykh Abdillah SulaymÄn Ibn Nasir Ibn âAbdillah Al-âUlwan Language: English | Format: PDF | Pages: 50 | Size: 1 MB This small treatise from the noble Shaykh, ImÄm SulaymÄn Ibn NÄsir Al-âUlwÄn, may AllÄh free him, is both topical and relevant, concerning the current state of affairs which the IslÄmic nation is now facing. And due to this fact, we found it beneficial for the many English speaking Muslims to read and perhaps learn and grasp its...
Topic: Verily The Victory Of Allah Is Near.pdf
Arxiv.org
by Kiri L. Wagstaff; Benyang Tang; David R. Thompson; Shakeh Khudikyan; Jane Wyngaard; Adam T. Deller; Divya Palaniswamy; Steven J. Tingay; Randall B. Wayth
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Time domain radio astronomy observing campaigns frequently generate large volumes of data. Our goal is to develop automated methods that can identify events of interest buried within the larger data stream. The V-FASTR fast transient system was designed to detect rare fast radio bursts (FRBs) within data collected by the Very Long Baseline Array. The resulting event candidates constitute a significant burden in terms of subsequent human reviewing time. We have trained and deployed a machine...
Topics: Astrophysics, Instrumentation and Methods for Astrophysics
Source: http://arxiv.org/abs/1606.08605
PubMed Central
by Parker, Dane; Planet, Paul J.; Soong, Grace; Narechania, Apurva; Prince, Alice
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This article is from PLoS Pathogens , volume 10 . Abstract The tremendous success of S. aureus as a human pathogen has been explained primarily by its array of virulence factors that enable the organism to evade host immunity. Perhaps equally important, but less well understood, is the importance of the intensity of the host response in determining the extent of pathology induced by S. aureus infection, particularly in the pathogenesis of pneumonia. We compared the pathogenesis of infection...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930619
Defense Technical Information Archive
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The successful treatment of breast cancer requires detection of the disease at early stages. In this application, we propose to systematically isolate secreted and cell surface proteins (trafficked proteins) with increased expression in early stage breast tumors. These proteins are candidates for blood-borne markers and cell surface markers that can be used in the routine screening of early stage breast cancer. We proposed to isolate all trafficked proteins from breast tumors using a functional...
Topics: DTIC Archive, Sun, Peiqing, SCRIPPS RESEARCH INST LA JOLLA CA, *DIAGNOSIS(MEDICINE), *BREAST...
Defense Technical Information Archive
by Defense Technical Information Center
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The cell cycle inhibitor p27kip1 has been implicated in a wide array of human cancers, including breast cancer. The overall goal of this research is to understand the role of p27kip1 as a tumor suppressor by studying the interaction of p27 with other genes, particularly p130, a member of the Retinoblastoma protein family, in multi-step cancer. We have used insertional mutagenesis in p27-null mice to create a model of p27- associated lymphomas and have identified myc genes and several candidate...
Topics: DTIC Archive, Clurman, Bruce E, FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA, *MAMMARY GLANDS,...
Defense Technical Information Archive
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Raytheon's Infrared Operations (RIO) has invented and developed a new type of focal plane array with Image Processing on-the-chip named the Adaptive IR Sensor (AIRS). The AIRS FPA is based upon the human retina in that it performs signal processing near the photoreceptors. The AIRS FPA has been reduced to practice and adaptively removes detector and optic temperature drift and 1/f induced fixed pattern noise. This 3rd-generation multi-mode IRFPA, also called a Smart FPA, is a 256x256-array...
Topics: DTIC Archive, Caulfield, J T, AIR FORCE RESEARCH LAB EGLIN AFB FL, *INFRARED EQUIPMENT, *FOCAL...
Defense Technical Information Archive
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As described in our research proposal the MUC1 gene is expressed in secretory epithelial tissues and at exceptionally high levels in human breast cancer cells. It is a well-known and widely accepted marker for breast cancer that can generate several functionally distinct MUC1 protein isoforms some containing a 20 amino acid tandem-repeat-array and additional forms lacking this domain. Findings emanating originally from our laboratory and subsequently confirmed by others, implicate the...
Topics: DTIC Archive, Wreschner, Daniel H, TEL-AVIV UNIV (ISRAEL), *EPITHELIUM, *GENES, *BREAST CANCER,...
The elucidation upon fly's neuronal patterns as a link to computer graphics and memory cards I/O's, is investigated for the phenomenon by propounding a unified theory of Einstein's two known relativities. It is conclusive that flies could contribute a certain amount of neuromatrices indicating an imagery function of a visual-computational system into computer graphics and storage systems. The visual system involves the time aspect, whereas flies possess faster pulses compared to humans' visual...
Source: http://arxiv.org/abs/0710.0410v1